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Apr 28, 2024
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2014-2015 Academic Catalog [Archived Catalog]
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BIOL 497 - VACCINES: FROM CONCEPTS TO DEVELOPMENT
Credits: Variable between 1 and 4
Vaccines have literally transformed the landscape of medicine over the course of the 20th century. Vaccines have reduced and, in some cases, eliminated many diseases that killed or severely disabled people just a few generations before. For most Americans today, vaccines are a routine part of healthcare. The course will begin with a review of the history of vaccine development and usage. To better understand this important medical innovation, the basics in modern immunology, infectious disease, and antigen identification will then be covered. The remainder of the course will focus on vaccine strategies; the traditional killed and live attenuated, vaccines and the modern molecular approaches such as microbial vectored, DNAmediated, subunit, and synthetic vaccines. The role of antigen presentation, adjuvants, and differential T-cell and B-cell stimulation will be stressed. The course will conclude with consideration of the challenges facing vaccine development, including the belief of many parents that vaccine use leads to autism and other diseases, financing vaccine R & D, and society’s expectations for vaccines.
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